I use color a color management system and calibrate by the job - sometimes several times daily. After I set the color profile, I use the "Develop Settings" tool to copy the settings from a color chart that contains the custom profile, has been color balanced, adjusted for density, etc. When I "Paste Settings" to the files taken within that job (sometimes hundreds), the "(color) Profile" is grayed-out. I am forced to open an earlier version of ACR to copy the profile to the images.